Caspases

A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.

Also Known As:

Caspase

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Hydrolases: 2206
    - Peptide Hydrolases: 24289
      - Cysteine Proteases: 1994
        Cysteine Endopeptidases: 4
        Caspases: 9499
      - Endopeptidases: 643
        Cysteine Endopeptidases: 4
        Caspases: 9499
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Intracellular Signaling Peptides and Proteins: 32
    - Apoptosis Regulatory Proteins: 2581
      - Caspases: 9499

Violeta Gomez-Vicente Selected Research

Violeta Gomez-Vicente Research Topics

Disease

Drug/Important Bio-Agent (IBA)